List of API intermediates

S.No. API Intermediate Name CAS #
1 Apixaban 3-morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5, 6- dihydropyridin-2(1H)-one 545445-44-1
2 Apixaban (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono) acetate 27143-07-3
3 Apixaban 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one 503615-03-0
4 Apixaban Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin- 1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 503614-91-3
5 Apremilast 3-Acetamidophthalic anhydride 6296-53-3
6 Apremilast (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine 608141-42-0
7 Aripiprazole 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-uinolinone 129722-34-5
8 Atorvastatin Calcium Tert-Butyl(4R,6R)-2-[[[6-(2-4-fluorophenyl)-5- isopropyl-3-phenyl-4-(phenylcarbamoyl) pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3dioxan-4-yl]acetate 125971-95-1
9 Clopidogrel Methyl-(4,5,6,7-tetrahydro-5-thieno [3,2-c] pyridyl) (2-chlorophenyl) acetate hydrochloride 144750-52-7
10 Clopidogrel S(+)-2-(2-Chloropheny)-6,7-dihydrothieno (3,2- C)pyridine-5(4H)-acetic acid methyl ester camphorsulfonate 120202-68-8
11 Dabigatran Etexilate Mesylate N-[3-Amino-4-(methyl amino)benzoyl]-N-2-pyridinyl- ethyl ester 212322-56-0
12 Dabigatran Etexilate Mesylate 2-(4-Cyanophenylamino) Acetic acid 42288-26-6
13 Dabigatran Etexilate Mesylate Ethyl 3-(2-(((4-cyanophenyl) amino) methyl)-1-methyl-

N-pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido) propanoate

211915-84-3
14 Dabigatran Etexilate Mesylate Ethyl 3-2-(4-amidinophenylamino) methyl)-1-methyl- N-(pyridin-2yl)-1H-benzo[d]imidazole-5-carboxamido) propanoate. 429658-95-7
15 Dabigatran Etexilate Mesylate Ethyl 3-{[(2-{[(4-{N’-[(Hexyloxy) carbonyl] carbamimidoyl} phenyl) amino]methyl}-l-methyl- lH- benzimidazol-5-yl)carbonyl] (2-yridinyl)amino}propanoate 211915-06-9
16 Dabigatran Etexilate Mesylate Ethyl 3-[[2-[[4-(E)-N1-hexyloxycarbonyl carbamimidoyl] aniline] methyl]-1- methylbenzimidazole-5-carbonyl] pyridin-2-ylamino] propanoate 1408238-36-7
17 Deferasirox 2-(2-Hydroxy phenyl)benz(e)[1,3]-oxazin-4-one. 1218-69-5
18 Deferasirox 4-hydrazino benzoic Acid 619-67-0
19 Doxazosin Mesylate N-(1,4-Benzodioxan-2-carbonyl)piperazine 70918-00-2
20 Doxazosin Mesylate 4-Amino-2-chloro-6,7-dimethoxyquinazoline 23680-84-4
21 Eletriptan Hydrobromide (R)-5-Bromo-3-((1-methyl-2-pyrrolidinyl) methyl] -1H-indole 143322-57-0
22 Esomeprazole magnesium 6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt (1:1) 161796-84-5
23 Fluvoxamine Maleate 5-Methoxy-1-[4-(trifluoromethyl) phenyl]-1-pentanone 61718-80-7
24 Labetalol HCL 5-Bromoacetyl Salicylamide 73866-23-6
25 Lamotrigine 2-(2,3-Dichlorophenyl)-2-(guanidinylamino)acetonitrile 84689-20-3
26 Lansoprazole 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl] methyl]thio]-1H-benzimidazole 103577-40-8
27 Linagliptin (R)-tert-butyl 1-(7-but-2-ynyl)-3-methyl-1-((4- methylquinazoin-2-yl) methyl)-2,6-dioxo-2,3,6,7- tetrahydro-1H-purin-8-yl)piperidin-3-yl carbamate. 668273-75-4
28 Mirabegron 4-Nitrophenethylamine hydrochloride 29968-78-3
29 Mirabegron 2-Aminothiazol-4-acetic acid 29676-71-9
30 Mirabegron 2-Aminothiazol-4-acetic acid Hydrochloride 66659-20-9
31 Mirabegron (R)-2-Hydroxy-N-(4-nitrophenethyl)-2- phenylacetamide 521284-19-5
32 Mirabegron (alpha R)-alpha –***2- (4-nitrophenyl) ethyl+ amino+ methyl]benzene methanol Hydrochloride 521284-21-9
33 Mirabegron (alpha R)-alpha –***2-(4-nitrophenyl)ethyl+ amino]methyl] benzene methanol 27 (1R) -2-[[2-(4-aminophenyl 223673-34-5
34 Mirabegron (R) -2-[2-(4-amino-phenyl) ethylamino] -1-phenyl- ethanol HCl 521284-22-0
35 Omeprazole 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl]thio]-1H -benzimidazole. 73590-85-9
36 Oseltamivir

Phosphate

Ethyl (3R, 4S, 5S)- 4,5-epoxy-3-(1-ethyl-propoxy) cyclohex-1-ene-1-carboxylate 204254-96-6
37 Oseltamivir

Phosphate

Ethyl (3R,4R,5S)-4-acetamido-5-azido-3-(1-

ethylpropoxy)-1 -cyclohexene-1-carboxylate

204255-06-1
38 Oseltamivir Phosphate Ethyl (3R, 4S, 5S)-4, N-acetyl (1,1-dimethyl ethyl)

amino-5-N,N-diallylamino-3- (1-ethylpropoxy)-1- cyclohexene-1-carboxylate hydrochloride

651324-08-2
39 Pantoprazole

Sodium Sesquihydrate

5-Difluoromethoxy-2-{[(3, 4-dimethoxy-pyridin-2- yl)methyl]thio}-1H -benzimidazole. 102625-64-9
40 Paroxetine HCL (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1- methylpiperidine 105812-81-5
41 Perampanel 5′-bromo-1′-phenyl-[2,3′-bipyridin]-6′(1’H)-one 381248-06-2
42 Pirfenidone 5-Methylpyridin-2(1H)-one 1003-68-5
43 Prasurgrel 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
44 Prasurgrel 5, 6,7,7a-Tetrahydrothieno(3,2-c]pyridine-2(4H)-one hydrochloride 115473-15-9
45 Raloxifene 4-(2-Piperidin-1-yl-ethoxy)benzoic acid hydrochloride 1246815-60-0
46 Raloxifene 6-Methoxy-2-(4-methoxyphenyl) benzo [b] thiophene 63675-74-1
47 Raltegravir Methyl 2-[[(benzyloxy) carbonyl] amino]-1- methylethyl]- 1methyl-5-hydroxy-6-Oxo-1, 6-dihydroxy pyrimidine-4-carboxylate. 888504-27-6
48 Raltegravir Benzyl [1-[4-[[(4-fluorobenzyl) amino]carbonyl] -5- hydroxy-1-methyl- 6-oxo-1,6-dihydropyrimidin-2-yl] -1-methylethyl] carbamate 518048-02-7
49 Raltegravir 5-Methyl-1,3,4-oxadiazole-2-carboxilic acid potassium salt. 888504-28-7
50 Ranolazine 1-[N-(2,6-Dimethylphenyl)carbamoyl methyl] piperazine 5294-61-1
51 Ranolazine 1-(2-Methoxyphenoxy)-2,3-epoxypropane 2210-74-4
52 Rivaroxaban 4-(4-aminophenyl)morpholin-3-one 438056-69-0
53 Rivaroxaban S(+) -Glycidyl phthamide 161596-47-0
54 Rivaroxaban 5-chlorothiophene-2-carboxylic acid 24065-33-6
55 Rivaroxaban 2-[(2R)-2-Hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl] amino} propyl]-1H-isoindole-1,3(2H)-dione 446292-07-5
56 Rivaroxaban (S)-2-((2-oxo-3-(4-(3-oxo-morpholino)phenyl) oxazolidin-5-yl)methyl)isoindoline- 1,3-dione 446292-08-6
57 Rivaroxaban 4 -[4-[(5S)-5-(Aminomethyl)-2-oxo-3- oxazolidinyl]phenyl]-3-morpholinone Hydrochloride 898543-06-1
58 Sofosbuvir N-((s)-(2,3,4,5,6-Pentafluorophenoxy) phenoxyphosphinyl)-L-alanine methylethyl ester 1334513-02-8
59 Tadalafil 1,2,3,4-Tetrhydro-2-chloroacetyl-1-(3,4-methylene dioxyphenyl)-9H-pyrido [3,4-B] indole-3- carobxylate CAS No. 171489-59-1
60 Teneligliptin 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl) piperazine 401566-79-8
61 Teneligliptin (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1- pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester 401564-36-1
62 Tolvaptan 7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl) amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine. 137973-76-3
63 Tolvaptan 7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-one 160129-45-3
64 Valacyclovir Hydrochloride Monohydrate 2-[(2-amino-1,6-dihydro-6-oxo-9H -purin-9-yl) methoxy] ethyl N-[(phenylmethoxy)carbonyl]-L-valinate 124832-31-1
65 Valgancyclovir N -(benzyloxycarbonyl)-L-valine-2-[(2-amino-1,6- dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester 194154-40-0
66 Valgancyclovir Ganciclovir Monoacetate 88110-89-8
67 Voriconazole 1-(2,4-Difluorophenyl)-2-(1H-1 ,2,4-triazole-1-yl) ethanone 86404-63-9
68 Voriconazole 4-chloro-6-ethyl-5-fluoropymidine 137234-74-3
69 Diclofenac Sodium 2,6 Dichloro Diphenyl Amine 15307-93-4
70 Diclofenac Sodium N chloro acetyl 2 6 dichloro diphenyl amine 15308-01-7
71 Diclofenac Sodium 1-(2,6-DICHLOROPHENYL)-2-INDOLINONE 15362-40-0
72 Teneligliptin 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl) piperazine 401566-79-8
73 Teneligliptin (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester 401564-36-1
74 Itopride Veratric Acid 93-07-2
75 Sitagliptin Keto Sitagliptin 764667-65-4
76 Sitagliptin 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine HCl 762240-92-6
77 Labetalol 5-bromoacetylsalicylamide 40187-51-7